Endocrine Abstracts

Heterophilic antibodies are well-known interferent factors affecting most immunoassays. However, they have been poorly evaluated in routine clinical practice. Definition of Subclinical Cushing’s Syndrome (SCs) has been arbitrary and prevalence has shown significant variations related with the diversity of the diagnostic tests. In most of the guidelines a low or suppressed corticothropin (ACTH) level has been suggested as an important predictor of SCs. Here, we sought to i...

A 21-year-old female (height: 148 cm, weight: 38 kg, and BMI: 17) was referred to our endocrinology outpatient polyclinic with the complaints of severe abdominal pain and severe hypertriglyceridemia. The patient’s medical history revealed diabetes and FMF. Physical examination revealed a marked loss of subcutaneous fat from the extremities leading to prominence of muscular contours and veins, with excess fat around the face, submental and dorsocervical region. Despite the...

Background and aim: Oral contraceptives (OC) are the mainstay of long-term treatment for women with polycystic ovary syndrome (PCOS). OC use is associated with increased risk of venous thromboembolism. The aim of the present study was to determine whether treatment with a low dose OC induce changes on coagulation and fibrinolysis in women with PCOS.Materials and methods: Sixteen lean, normal-glucose tolerant patients with PCOS (mean age, 22.4±2.4 ye...

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

Objective: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a very rare congenital anomaly characterised by vaginal agenesis and a spectrum of different genitourinary tract anomalies. Typical form of this syndrome is characterised by congenital absence of the uterus and upper 2/3 vagina with normal ovaries and fallopian tubes and atypical form of the syndrome is associated with anomalies of the ovaries and fallopian tubes and renal anomalies.Case r...

A 37-year-old patient with a history of transcranial pituitary surgery because of acromegaly was referred to our clinic with the glucose level 731 mg/dl. she was not using any medication. There was no ketone in the urine and HbA1c was 18.6%. She has 17×16×15 mm of residual macroadenoma on pıtuıtary MRI with level of GH 17.5 ng/ml and IGF-1 422 ng/ml. She was using 140 units of insulin glargin U300 and 100 units of insulin regular per a day before octreotide...

Introduction: Childhood obesity has become an important health problem nowadays. Intracranial lesions (IC) can affect the hypothalamic - hypophyseal axis depending on the localization of the lesion and lead to hypophyseal hormone deficiencies, especially growth hormone. Although IC lesions are important in the etiology of obesity, There’s limited data in the literature about this subject. Aim of this study is to evaluate the incidence of IC lesions and their role in clini...

Subclinical Cushing’s syndrome (SCs) is used to refer to an adrenal incidentaloma with subtle autonomous cortisol secretion and without typical signs and symptoms of hypercortisolism. Diagnostic criteria are uncertain and arbitrary. In this study we aimed to investigate the power of adenoma size as an independent predictor of SCs.Dokuz Eylul University Adrenal Tumours Study Group database includes 596 patients by January 2016. Briefly, there are 332...

Introduction: Oxidative stress is one of the possible mechanisms involved in the pathogenesis of the obesity-related metabolic complication. In this study, we aimed to investigate effect of weight loss with bariatric surgery on IMA, high sensitive C-reactive protein (hs-CRP), serum total antioxidant status (TAS), total oxidant status (TOS) levels.Materials and methods: In this prospective study, plasma IMA, hs-CRP, TAS and TOS levels were measured before...

Introduction: Recent study showed that patients with acromegaly have typical skin findings including increased sebum secretion, decreased transepidermal water loss, more alkaline, and colder skin surface correlated with serum GH and IGF1 levels.The aim of this study was to demonstrate the effect of functional skin changes on the skin flora in patients with acromegaly.Methods and designs: This case–control study was conducted i...